関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-Methylbenzenesulfonamide | HCID 78858 | — |
| 反応物 | 2-Propenoic acid, 3-[4-(bromomethyl)phenyl]-, ethyl ester | HCID 24820373 | — |
| 反応物 | ethyl 4-(N-methylbenzenesulphonamidomethyl)-cinnamate | HCID 54517891 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(N-Methylbenzenesulphonamidomethyl)-cinnamic acid | HCID 54018757 | — |
反応手順
A mixture of 5.1 g. (30 mmol) N-methylbenzenesulphonamide, 8.8 g. (33 mmol) ethyl 4-bromomethyl-cinnamate (m.p. 47° C.), 4.1 g. (30 mmol) potassium carbonate and 50 ml. dimethylformamide are heated, with stirring, for 4 days at 60° C. The reaction mixture is then cooled and stirred into cold water and the organic components extracted with diethyl ether. The ethereal solution is washed with 0.5 N aqueous sodium hydroxide solution, dried with anhydrous sodium sulphate and evaporated. The residue is recrystallized from isopropanol to give 7.9 g. (73% of theory) ethyl 4-(N-methylbenzenesulphonamidomethyl)-cinnamate; m.p. 112°-112.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04443477 |
|---|
| 出典データセット | uspto-grants-1984_04 |
|---|
| ORD ID | ord-9e93730fa90a4a03b3cafe58dafd181e |
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| 出典メモ | uspto-grants-1984_04 |
|---|
