2-Chlorotoluene → 2-Chloro-6-nitrotoluene

HRID 326010

反応式

HRID 326010 の反応式
ClC1C=CC([N+:8]([O-:10])=[O:9])=CC=1C.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19]>>[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N+:8]([O-:10])=[O:9])[C:14]=1[CH3:19]

参加物

3

反応物 2

HCID 72382-ChlorotolueneHCID 83315Benzene, 1-chloro-2-methyl-4-nitro-

生成物 1

HCID 67402-Chloro-6-nitrotoluene収率 43%

実験手順

2-Chloro-5-nitrotoluene, which is required as a starting product, is accessible by nitrating o-chlorotoluene (Rec. Trav. Chim. Pays-Bas 32, (1913) 244 et seq.). It can be isolated from the resulting mixture of isomers by distillation in 43% yield (Loc. cit. 286). This distillation gives pure 2-chloro-6-nitrotoluene as first runnings the other isomers can be separated in a known way. Since all isomers, by virtue of their reactive groups, are intermediates which can be put to many uses and for which there is adequate demand, no undesirable by-products are obtained in this reaction. Thus, even if this preliminary stage is included, this invention represents a very favorable procedure.

後処理

  1. customIt can be isolated from the resulting mixture of isomers by distillation in 43% yield (Loc. cit. 286)
  2. distillationThis distillation

出典と根拠

ORDレコード
ord-d37dc916f1ba4f4c875f475a135d219a
出典データセット
uspto-grants-1984_04
特許番号
US04443630

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