関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | 4,5-Pyrimidinediamine, 6-chloro- | HCID 78010 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | 6-Iodopyrimidine-4,5-diamine | HCID 17965894 | 98% |
反応手順
6-Chloropyrimidine-4,5-diamine (Intermediate 88) (90 mg) was added slowly to HI (57%, aq) (2 mL) at 0° C. The reaction mixture was allowed to stir at 0° C. for 30 minutes and then at ambient temperature for 24 hours. NaHCO3 (sat aq.) was added dropwise until the reaction mixture was pH 8. The product was extracted with EtOAc (3×15 mL). The combined organics were dried (MgSO4), filtered and concentrated in vacuo to afford the title compound as a grey solid (144 mg, 98%);
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07427616B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-36d650d9bef54b7e970ce0e95d3a1b3e |
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| 出典メモ | uspto-grants-2008_09 |
|---|
