Quinoline → Ethyl 2-[4-(6-fluoroquinolin-2-yloxy)phenoxy]-propionate

HRID 326038ノート

反応式

HRID 326038 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([F:12])[CH:8]=2)[N:3]=1.[OH:13][C:14]1[CH:27]=[CH:26][C:17]([O:18][CH:19]([CH3:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:16][CH:15]=1.N1C2C(=CC=CC=2)C=CC=1>>[F:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([O:13][C:14]1[CH:15]=[CH:16][C:17]([O:18][CH:19]([CH3:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:26][CH:27]=1)[CH:11]=[CH:10]2

参加物

4

反応物 3

HCID 7047QuinolineHCID 3017597Propanoic acid, 2-(4-hydroxyphenoxy)-, ethyl esterHCID 150594332-Chloro-6-fluoroquinoline

生成物 1

HCID 13747392Ethyl 2-[4-(6-fluoroquinolin-2-yloxy)phenoxy]-propionate

実験手順

was prepared from 2-chloro-6-fluoroquinoline and ethyl 2-(4-hydroxyphenoxy)propionate following essentially the same procedure as that described in Example 1. The compound was isolated as a pale yellow oil. Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 8.1-6.8 (9H, m, quinoline and phenyl protons); 4.8 (1H, q, CH-CH3); 4.3 (2H, q, OCH2 -CH3); 1.6 (3H, d, CH-CH3); 1.2 (3H, t, OCH2 -CH3).

後処理

  1. customThe compound was isolated as a pale yellow oil

出典と根拠

ORDレコード
ord-c345f2fe40c84c95b8d6da4a3745f10c
出典データセット
uspto-grants-1984_04
特許番号
US04444584

反応ノート

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