Quinoline → Ethyl 2-[4-(3-nitroquinolin-4-yloxy)phenoxy]propionate

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[OH:15][C:16]1[CH:29]=[CH:28][C:19]([O:20][CH:21]([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:18][CH:17]=1.N1C2C(=CC=CC=2)C=CC=1>>[N+:12]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[O:15][C:16]1[CH:17]=[CH:18][C:19]([O:20][CH:21]([CH3:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:28][CH:29]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2)([O-:14])=[O:13]

参加物

反応物 3

HCID 7047Quinoline

HCID 3017597Propanoic acid, 2-(4-hydroxyphenoxy)-, ethyl ester

HCID 112758084-Chloro-3-nitroquinoline

生成物 1

HCID 20461943Ethyl 2-[4-(3-nitroquinolin-4-yloxy)phenoxy]propionate

実験手順

Ethyl 2-[4-(3-nitroquinolin-4-yloxy)phenoxy]propionate (41) was prepared from 4-chloro-3-nitroquinoline and ethyl 2-(4-hydroxyphenoxy)propionate following essentially the same procedure as that described in Example 1. The compound was isolated as a yellow oil. Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 9.3 (1H, s); 8.3-7.4 (4H, m, quinoline protons); 6.8 (4H, s, phenoxy protons); 4.7 (1H, q, CH--CH3); 4.2 (2H, q, OCH2 --CH3); 1.6 (3H, d, CH--CH3); 1.2 (3H, t, OCH2 --CH3).

後処理

customThe compound was isolated as a yellow oil

出典と根拠

ORDレコード: ord-d10dd75f0ecb40c78bfc1d34217c79f7
出典データセット: uspto-grants-1984_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04444584

反応ノート

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