1,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2) → Benzathine

HRID 326062

反応式

HRID 326062 の反応式
C(O)(=O)C.C(O)(=O)C.[CH2:9]([NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>O>[CH2:9]([NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

3

反応物 1

HCID 312281,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2)

生成物 1

HCID 8793Benzathine

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

306 mg. (0.001 ml) of BL-P2013 was dissolved in 7 ml. H2O and added to a solution of 180 mg. (0.0005 mol) of N,N'-dibenzylethylenediamine diacetate in 7 ml. H2O. The mixture was stirred and the salt crystallized and after stirring approximately 10-15 minutes the salt was collected by filtration and air dried to yield N,N'-dibenzylethylenediamine salt of BL-P2013 (300 mg). The material was recrystallized by dissolving it in approximately 10 ml. of boiling acetone and diluting with ether to the cloud point. 260 mg. of air dried and vacuum dried material was obtained.

後処理

  1. customthe salt crystallized
  2. stirringafter stirring approximately 10-15 minutes the salt
  3. filtrationwas collected by filtration and air
  4. customdried

出典と根拠

ORDレコード
ord-794f9ad4822a4f868355d1e59d69d996
出典データセット
uspto-grants-1984_04
特許番号
US04444687

関連ノート

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