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1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one → 2-Ethyl-7-(3-pyridyl)[1,2,4]triazolo[1,5-a]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one | HCID 567033 | — |
| 反応物 | 5-ethyl-1H-1,2,4-triazol-3-amine | HCID 1714204 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Ethyl-7-(3-pyridyl)[1,2,4]triazolo[1,5-a]pyrimidine | HCID 13309049 | 67.1% |
反応手順
A mixture of 1.12 g of 3-amino-5-ethyl-1,2,4-triazole and 1.76 g of 3-dimethylamino-1-(3-pyridyl)-2-propene-1-one in 25 ml of glacial acetic acid was refluxed for six hours and the procedure of Example 1 was continued to give 1.51 g of the desired product as colorless needles, mp 147°-149° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04444774 |
| 出典データセット | uspto-grants-1984_04 |
| ORD ID | ord-31677377b23d444bafe5892f8d4658f0 |
| 出典メモ | uspto-grants-1984_04 |