Acetic Acid → N-(3-formyl-2-methylphenyl)acetamide
反応式
[CH3:1][C:2]1[C:9]([NH2:10])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#N.[C:11](OC(=O)C)(=[O:13])[CH3:12].C(O)(=[O:20])C>>[CH3:1][C:2]1[C:9]([NH:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:20]参加物
4
実験手順
39 g (0.3 mole) of 2-methyl-3-amino-benzonitrile were dissolved in 75 ml of acetic acid, 30 ml (0.3 mole) of acetic anhydride were added, the mixture was heated with reflux for 5 minutes, and cooled. The solid obtained was filtered off an the evaporation of the solvent furnished an additional quantity of solid which was added to the preceding one. After recrystallisation of the whole from toluene, 44 g (95%) of colourless flakes were obtained, with a melting point of 160° C.
後処理
- temperaturethe mixture was heated
- temperaturewith reflux for 5 minutes
- temperaturecooled
- customThe solid obtained
- filtrationwas filtered off an
- customthe evaporation of the solvent
- customfurnished an additional quantity of solid which
- additionwas added to the preceding one
- customAfter recrystallisation of the whole from toluene, 44 g (95%) of colourless flakes
- customwere obtained, with a melting point of 160° C.
出典と根拠
- ORDレコード
- ord-d739e76f6b5e48e680805541cff11c6f
- 出典データセット
- uspto-grants-1984_04
- 特許番号
- US04444776
反応ノート
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