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Potassium Cyanide → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Dibenzo-18-crown-6 | HCID 26541 | — |
| 反応物 | 5-(5-Chloropentyl)imidazo[1,5-a]pyridine | HCID 20446676 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 5-(5-Cyanopentyl)-imidazo[1,5-a]pyridine hydrochloride | HCID 20446665 | — |
反応手順
A solution of 37 g of 5-(5-chloropentyl)-imidazo[1,5-a]pyridine, 21.7 g of potassium cyanide and 3 g of dibenzo-18-crown-6 in acetonitrile is heated under reflux for 20 hours. The acetonitrile is evaporated under reduced pressure, the residue is partitioned between water and methylene chloride, and the methylene chloride extract is evaporated to dryness. Treatment of a solution of the residue in ether with ethanolic hydrochloric acid yields 5-(5-cyanopentyl)-imidazo[1,5-a]pyridine hydrochloride melting at 178°-80°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04444775 |
| 出典データセット | uspto-grants-1984_04 |
| ORD ID | ord-82c685267c444f88a9989255cbbb1444 |
| 出典メモ | uspto-grants-1984_04 |