Methylamine → 5-[5-(N-methylcarbamoyl)pentyl]imidazo[1,5-a]pyridine
反応式
C(O[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:16]2[CH:17]=[N:18][CH:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)=[O:5])C.[CH3:20][NH2:21]>C(O)CCC>[CH3:20][NH:21][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:16]2[CH:17]=[N:18][CH:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)=[O:5]参加物
4
実験手順
A solution of 3.9 g of 5-(5-ethoxycarbonylpentyl)-imidazo[1,5-a]pyridine in 40 ml of n-butanol is saturated with methylamine and heated on a steam bath for 56 hours in a pressure bottle. The reaction mixture is evaporated to dryness; the resulting product is first crystallized from ether and then recrystallized from 1:1 ethyl acetate-ether to yield the 5-[5-(N-methylcarbamoyl)pentyl]-imidazo[1,5-a]pyridine melting at 118°-22°.
後処理
- temperatureheated on a steam bath for 56 hours in a pressure bottle
- customThe reaction mixture is evaporated to dryness
- customthe resulting product is first crystallized from ether
- customrecrystallized from 1:1 ethyl acetate-ether
出典と根拠
- ORDレコード
- ord-925320fd79ae4a80a92b4e3b57e3f5e0
- 出典データセット
- uspto-grants-1984_04
- 特許番号
- US04444775
反応ノート
読み込み中…