Vanillin → 2-[2-(4-Hydroxy-3-methoxyphenyl)-ethenyl]-quinoline

HRID 326173

反応式

HRID 326173 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[C:18]([CH:20]=O)[CH:17]=[CH:16][C:15]=1[OH:22]>C(OC(=O)C)(=O)C>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([CH:20]=[CH:1][C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[CH:19][C:14]=1[O:13][CH3:12]

参加物

4

反応物 2

HCID 1183VanillinHCID 70602-Methylquinoline

生成物 1

HCID 6239702-[2-(4-Hydroxy-3-methoxyphenyl)-ethenyl]-quinoline収率 63%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

In 61.34 g of acetic anhydride, 34.40 g of 2-methylquinoline and 36.57 g of vanilin were allowed to react with each other under reflux for 16 hours, and 50 cm3 of acetic acid was expelled by distillation. The residue and 250 cm3 of 3 N hydrochloric acid added thereto were heated for one hour. The heated mixture was cooled to deposit crystals, which were separated by filtration. The crystals were suspended in aqueous ammonia and stirred for one hour to expel hydrogen chloride from the crystals. The crystals thus freed from hydrogen chloride were again separated by filtration and collected. They were recrystallized via 2-ethoxyethanol to afford 2-[2-(4-hydroxy-3-methoxyphenyl)-ethenyl]-quinoline in a yield of 63%.

後処理

  1. customto react with each other
  2. temperatureunder reflux for 16 hours
  3. distillation50 cm3 of acetic acid was expelled by distillation
  4. additionThe residue and 250 cm3 of 3 N hydrochloric acid added
  5. temperaturethereto were heated for one hour
  6. temperatureThe heated mixture was cooled
  7. customwere separated by filtration
  8. customwere again separated by filtration
  9. customcollected
  10. customThey were recrystallized via 2-ethoxyethanol

出典と根拠

ORDレコード
ord-387d3573d2a747e3b3a4c0d03dbf8937
出典データセット
uspto-grants-1984_04
特許番号
US04444868

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