Water → 2-{2-[3-Methoxy-4-(2-hydroxy-3-methacryloyloxypropyloxy)-phenyl]-ethenyl}-quinoline

HRID 326174

反応式

HRID 326174 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[CH:4][C:3]=1[O:20][CH3:21].[C:22]([O:27][CH2:28][CH:29]1[O:31][CH2:30]1)(=[O:26])[C:23]([CH3:25])=[CH2:24].O>CN(C)C(=O)C.[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH3:21][O:20][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH:6]=[CH:7][C:2]=1[O:1][CH2:30][CH:29]([OH:31])[CH2:28][O:27][C:22](=[O:26])[C:23]([CH3:25])=[CH2:24]

参加物

6

反応物 3

HCID 962WaterHCID 7837Glycidyl methacrylateHCID 6239702-[2-(4-Hydroxy-3-methoxyphenyl)-ethenyl]-quinoline

生成物 1

HCID 543279402-{2-[3-Methoxy-4-(2-hydroxy-3-methacryloyloxypropyloxy)-phenyl]-ethenyl}-quinoline収率 50%

試薬・触媒・溶媒 2

HCID 70681Tetrabutylammonium Chloride触媒HCID 31374Dimethylacetamide溶媒

実験手順

In 5 cm3 of N,N-dimethylacetamide, 2.77 g of the produced quinoline derivative was dissolved and 1.42 g of glycidyl methacrylate and 0.10 g of tetrabutylammonium chloride were added thereto. The resultant mixture was reacted by maintaining it at 90° to 100° C. for 5 hours. The reaction product was mixed with water. The oily substance separated consequently was extracted via ethyl acetate, washed thoroughly with water, and dried. The dry product was distilled to expel the solvent and then separated and purified by silica gel chromatography, to afford 2-{2-[3-methoxy-4-(2-hydroxy-3-methacryloyloxypropyloxy)-phenyl]-ethenyl}-quinoline in a yield of 50%. When this product was recrystallized via ethyl acetatehexane, there was obtained a pure product having a melting point of 119° C. It was identified by elementary analysis and infrared absorption spectrometry.

後処理

  1. temperatureby maintaining it at 90° to 100° C. for 5 hours
  2. customThe oily substance separated consequently
  3. extractionwas extracted via ethyl acetate
  4. washwashed thoroughly with water
  5. customdried
  6. distillationThe dry product was distilled
  7. customseparated
  8. custompurified by silica gel chromatography

出典と根拠

ORDレコード
ord-937b96f9883c4dc3af7a5c24d204bfd7
出典データセット
uspto-grants-1984_04
特許番号
US04444868

関連ノート

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