2,4-Dichlorotoluene → 5-Bromo-2,4-dichlorotoluene

HRID 326178

反応式

HRID 326178 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[Cl-].[Al+3].[Cl-].[Cl-].[Br:14]Br>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([Br:14])=[CH:4][C:3]=1[CH3:9]

参加物

4

反応物 3

HCID 72542,4-DichlorotolueneHCID 24408BromineHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 204627725-Bromo-2,4-dichlorotoluene

実験手順

500 parts of 2,4-dichlorotoluene (b.p.=198° to 200° C.) and 10 parts of anhydrous aluminum chloride were charged into a 1-liter four-necked flask provided with a reflux condenser, a thermometer, a stirrer and a dropping funnel. 397 parts of bromine was added dropwisely at 30° to 40° C. over a period of 5 hours. The reaction liquid was washed with warm water followed by separating the water layer, and then the oil layer was cooled. The separated crystals were filtered off, recrystallized from methanol to obtain 295 parts of 2,4-dichloro-5-bromotoluene having a melting point of 82.5° to 84.0° C.

後処理

  1. customprovided with a reflux condenser
  2. customThe reaction liquid
  3. washwas washed with warm water
  4. customby separating the water layer
  5. temperaturethe oil layer was cooled
  6. filtrationThe separated crystals were filtered off
  7. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-1b4b73c2a2624b469563fe3b1ae542f6
出典データセット
uspto-grants-1984_04
特許番号
US04444983

関連ノート

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