Bromine → 1-Bromo-4-chloro-2,5-dimethylbenzene

HRID 326179

反応式

HRID 326179 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[Cl-].[Al+3].[Cl-].[Cl-].[Br:14]Br>O>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([Br:14])=[CH:4][C:3]=1[CH3:9]

参加物

5

反応物 3

HCID 24408BromineHCID 32883Chloro-p-xyleneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 180041871-Bromo-4-chloro-2,5-dimethylbenzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

400 parts of 2-chloro-p-xylene (b.p.=183° to 184° C.) and 2 parts of anhydrous aluminum chloride were charged into a 1-liter four-necked flask provided with a reflux condenser, a thermometer, a stirrer and a dropping funnel, to which 360 parts of bromine was dropwisely added over a period of 5 hours to carry out the reaction at 35° to 60° C. Water was added to the reaction liquid to wash the same with the thus added water and to remove the catalyst, and then the oil layer was cooled. The separated crystals were filtered, and washed with methanol to obtain 377 parts of 2-chloro-5-bromo-p-xylene having a melting point of 60° to 64° C.

後処理

  1. customprovided with a reflux condenser
  2. customthe reaction at 35° to 60° C
  3. washto wash the same with the thus added water
  4. customto remove the catalyst
  5. temperaturethe oil layer was cooled
  6. filtrationThe separated crystals were filtered
  7. washwashed with methanol

出典と根拠

ORDレコード
ord-f2c409d37d204f90b69cc7d1b4cfa72c
出典データセット
uspto-grants-1984_04
特許番号
US04444983

関連ノート

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