7-Quinolinemethanol → 7-Quinolinecarboxaldehyde

HRID 326248

反応式

HRID 326248 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][OH:12])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1>[O-2].[Mn+4].[O-2].ClCCl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=[O:12])[CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 976097-Quinolinemethanol

生成物 1

HCID 47122557-Quinolinecarboxaldehyde収率 94.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 8.6 parts of 7-quinolinemethanol, 20 parts of manganese(IV)oxide and 130 parts of dichloromethane was stirred for 24 hours at room temperature. The reaction mixture was filtered over diatomaceous earth and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; CH2Cl2 /CH3OH 98:2). The eluent of the desired fraction was evaporated, yielding 8 parts (94.2%) of 7-quinolinecarboxaldehyde; mp. 56° C. (interm. 1).

後処理

  1. filtrationThe reaction mixture was filtered over diatomaceous earth
  2. customthe filtrate was evaporated
  3. customThe residue was purified by column chromatography (silica gel; CH2Cl2 /CH3OH 98:2)
  4. customThe eluent of the desired fraction was evaporated

出典と根拠

ORDレコード
ord-c2909b5dbb8d4e4994c854d8f099dd41
出典データセット
uspto-grants-1993_12
特許番号
US05268380

関連ノート

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