Tetrabromophthalic anhydride → 2,3,4,5-Tetrabromo-6-[(4-chloro-2-fluoro-5-isopropoxycarbonyl-phenyl)carbamoyl]benzoic acid
反応式
[Br:1][C:2]1[C:3]([Br:15])=[C:4]([Br:14])[C:5]([Br:13])=[C:6]2[C:11](=[O:12])[O:10][C:8](=[O:9])[C:7]=12.[NH2:16][C:17]1[C:18]([F:30])=[CH:19][C:20]([Cl:29])=[C:21]([CH:28]=1)[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]>C1(C)C=CC=CC=1>[Br:13][C:5]1[C:4]([Br:14])=[C:3]([Br:15])[C:2]([Br:1])=[C:7]([C:8]([NH:16][C:17]2[CH:28]=[C:21]([C:22]([O:24][CH:25]([CH3:26])[CH3:27])=[O:23])[C:20]([Cl:29])=[CH:19][C:18]=2[F:30])=[O:9])[C:6]=1[C:11]([OH:10])=[O:12]参加物
4
実験手順
Tetrabromophthalic anhydride (6.67 g, 0.014 mole) and 1-methylethyl 5-amino-2-chloro-4-fluorobenzoate (3.33 g, 0.014 mole) were heated to reflux with stirring in about 150 ml of toluene, then left overnight at room temperature. Filtration of the reaction mixture gave the title compound, m.p. 160°-165° C. (decomp.).