Tetrachlorophthalic anhydride → 2,3,4,5-Tetrachloro-6-[(4-chloro-3-isopropoxycarbonyl-phenyl)carbamoyl]benzoic acid

HRID 326343

反応式

HRID 326343 の反応式
[Cl:1][C:2]1[C:3]([Cl:15])=[C:4]([Cl:14])[C:5]([Cl:13])=[C:6]2[C:11](=[O:12])[O:10][C:8](=[O:9])[C:7]=12.[NH2:16][C:17]1[CH:18]=[CH:19][C:20]([Cl:29])=[C:21]([CH:28]=1)[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]>C1(C)C=CC=CC=1>[Cl:13][C:5]1[C:4]([Cl:14])=[C:3]([Cl:15])[C:2]([Cl:1])=[C:7]([C:8]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([Cl:29])=[C:21]([C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23])[CH:28]=2)=[O:9])[C:6]=1[C:11]([OH:10])=[O:12]

参加物

4

反応物 2

HCID 8326Tetrachlorophthalic anhydrideHCID 369590Isopropyl 5-amino-2-chlorobenzoate

生成物 1

HCID 5032772,3,4,5-Tetrachloro-6-[(4-chloro-3-isopropoxycarbonyl-phenyl)carbamoyl]benzoic acid収率 70%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of tetrachlorophthalic anhydride (2.97 g, 0.010 mole), 1-methylethyl 5-amino-2-chlorobenzoate (2.22 g, 0.010 mole) and toluene (100 ml) was heated slowly to reflux with stirring, then left overnight at room temperature. Filtration of the reaction mixture gave the title compound, m.p. 178°-179° C. (3.45 g, 70% yield).

後処理

  1. temperaturewas heated slowly
  2. temperatureto reflux
  3. filtrationFiltration of the reaction mixture

出典と根拠

ORDレコード
ord-04dd752ccf414eb685ac6e3834415e2e
出典データセット
uspto-grants-1993_12
特許番号
US05268389

関連ノート

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