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Methyl morpholine oxide → 4-Phenyl-3-furaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl morpholine oxide | HCID 82029 | — |
| 反応物 | (4-Phenylfuran-3-yl)methanol | HCID 15037154 | — |
| 触媒 | HCID 178419074 | HCID 178419074 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Phenyl-3-furaldehyde | HCID 15037148 | — |
反応手順
A mixture of 4-phenyl-3-furanmethanol (458 mg, 2.63 mmol), powdered 4A molecular sieves (500 mg), 4-methyl-morpholine-N-oxide (462 mg, 3.95 mmol) and tetrapropylammonium perruthenate (46 mg, 0.13 mmol) in anhydrous dichloromethane (40 ml) were stirred at room temperature for 3 hours. Residue was filtered through silica and concentrated to a brown oil which was purified by flash chromatography on silica using 10% ethyl ether/hexanes to give the titled aldehyde.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05268387 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-ddae1b59dc504507827b5d46a07023df |
| 出典メモ | uspto-grants-1993_12 |