2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → N-{4-[5-(4-Aminothieno[2,3-d]pyrimidin-6-yl)-1-methyl-1H-imidazol-4-yl]phenyl}-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

HRID 32643

反応式

HRID 32643 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][N:11]([CH3:23])[C:12]=2[C:13]2[S:22][C:16]3[N:17]=[CH:18][N:19]=[C:20]([NH2:21])[C:15]=3[CH:14]=2)=[CH:4][CH:3]=1.NC1C=C(C2N=CN(C)C=2C2SC3N=CN=C(N)C=3C=2)C=CC=1.[F:47][C:48]1[CH:53]=[CH:52][C:51]([C:54]([F:57])([F:56])[F:55])=[CH:50][C:49]=1[N:58]=[C:59]=[O:60]>>[NH2:21][C:20]1[C:15]2[CH:14]=[C:13]([C:12]3[N:11]([CH3:23])[CH:10]=[N:9][C:8]=3[C:5]3[CH:6]=[CH:7][C:2]([NH:1][C:59]([NH:58][C:49]4[CH:50]=[C:51]([C:54]([F:55])([F:57])[F:56])[CH:52]=[CH:53][C:48]=4[F:47])=[O:60])=[CH:3][CH:4]=3)[S:22][C:16]=2[N:17]=[CH:18][N:19]=1

参加物

4

反応物 3

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 690543996-[4-(3-aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amineHCID 691971586-[4-(4-Aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine2 回

生成物 1

HCID 10482015N-{4-[5-(4-Aminothieno[2,3-d]pyrimidin-6-yl)-1-methyl-1H-imidazol-4-yl]phenyl}-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

実験手順

The title compound was prepared by a similar process to that described for Example 186 but using 6-[4-(4-aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Intermediate 112) in place of 6-[4-(3-aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Intermediate 110) and using 2-fluoro-5-trifluoromethylphenyl isocyanate in place of phenyl isocyanate. Colourless solid (48 mg, 73%);

出典と根拠

ORDレコード
ord-6b13e9bf308a4f08abc80bd2fe1a9029
出典データセット
uspto-grants-2008_09
特許番号
US07427616B2

関連ノート

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