Morpholine → 2-Morpholino-5-nitrobenzoic acid
反応式
F[C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>O1CCOCC1>[N:14]1([C:2]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1参加物
4
実験手順
To a solution of 2-Fluoro-5-nitrobenzoic acid (4.86 g, 26.2 mmol) in dioxane (50 ml) was added morpholine (11.5 ml). The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo. The residue was dissolved in water and the mixture was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide the title compound (6.2 g, 93%) as a yellow solid, MS (m/e): 251.2 (M−H, 100%).
後処理
- customThe solvent was removed in vacuo
- dissolutionThe residue was dissolved in water
- filtrationThe solid was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-2e70c48888a94a1d9855a29162203c8c
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07427612B2
反応ノート
読み込み中…