Ethanol → 1-(Benzothiophen-2-yl)piperazine
反応式
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:11]1[CH2:16][CH2:15]N[CH2:13][CH2:12]1.[CH2:17](O)C>>[S:3]1[C:2]([N:6]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[CH:17][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]1=2参加物
4
実験手順
2-Chlorobenzothiazole (5 g) is heated in ethanol (75 ml) with piperazine (3.05 g) for 20 h. The mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate. The organic phase is separated, dried with sodium sulfate and concentrated to give the title compound.
後処理
- customThe mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate
- customThe organic phase is separated
- dry with materialdried with sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-cf6e58f316fc4292a59846c68dcba790
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05268477
反応ノート
読み込み中…