Piperazine → HCID 15230687、化合物

HRID 326486

反応式

HRID 326486 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[N:3]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>C(O)C>[N:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:4]1[N:3]=[C:2]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:5]=1

参加物

4

反応物 2

HCID 4837PiperazineHCID 27670664-Chloro-2,6-di(2-pyridinyl)pyrimidine

生成物 1

HCID 15230687HCID 15230687、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Chloro-2,6-bis(2-pyridinyl)pyrimidine [prepared by the method of J.A.C.S. 32, 1591 (1967), 4.2 g] piperazine (13.44 g) and ethanol (70 ml) are heated at reflux for 2 hr. The mixture is allowed to cool and the solvent is removed under reduced pressure. The residue is dissolved in chloroform (250 ml), washed with water (twice), dried over sodium sulfate and concentrated under reduced pressure to give an oil. The oil is crystallized from ether to give the title compound, m.p. 159°-161°; MS (m/e) 318 (M+)

後処理

  1. temperatureat reflux for 2 hr
  2. temperatureto cool
  3. customthe solvent is removed under reduced pressure
  4. dissolutionThe residue is dissolved in chloroform (250 ml)
  5. washwashed with water (twice),
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customto give an oil
  9. customThe oil is crystallized from ether

出典と根拠

ORDレコード
ord-d26d616ce36f4a5f9230361590ebcac8
出典データセット
uspto-grants-1993_12
特許番号
US05268477

関連ノート

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