Hydrochloric Acid → Methyl 2-(4-hydroxyphenoxy)acetate

HRID 326558

反応式

HRID 326558 の反応式
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.Cl.[CH3:14]O>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]([O:10][CH3:14])=[O:9])=[CH:11][CH:12]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 15881(4-Hydroxyphenoxy)acetic acid

生成物 1

HCID 602731Methyl 2-(4-hydroxyphenoxy)acetate

実験手順

A solution of 4-hydroxyphenoxyacetic acid (33.6 g) in methanol was treated with hydrogen chloride gas and left to stand at ambient temperature overnight. The solvent was removed in vacuo and the residue taken up in ethyl acetate. This solution was washed sequentially with saturated sodium hydrogen carbonate solution (2×100 ml) and brine (100 ml), then dried (MGSO4) and the solvent evaporated to give methyl 4-hydroxyphenoxyacetate as a colourless crystalline mass, m.p. 112°-114° C.; NMR: 3.8 (s, 3H, CH3), 4.55 (s, 2H, CH2), 6.75 (s, 4H, phenyl-H) 6.8-7.8 (broad s, 1H, OH); m/e 200 (M+NH4)+.

後処理

  1. waitleft
  2. customThe solvent was removed in vacuo
  3. washThis solution was washed sequentially with saturated sodium hydrogen carbonate solution (2×100 ml) and brine (100 ml)
  4. customdried (MGSO4)
  5. customthe solvent evaporated

出典と根拠

ORDレコード
ord-933771ef539648ec8158ba86dfda7116
出典データセット
uspto-grants-1993_12
特許番号
US05270311

関連ノート

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