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Water → 2-Iodo-4-methyl-6-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Methyl-2-nitroaniline | HCID 6978 | — |
| 反応物 | Iodine chloride | HCID 24640 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Iodo-4-methyl-6-nitroaniline | HCID 19735199 | 25.6% |
反応手順
A solution of 4-amino-3-nitrotoluene (30.4 g) in acetic acid (250 ml) was refluxed with iodine monochloride (65.0 g) for 7 h with stirring, then was cooled and added to excess water. The precipitate was filtered off, washed with aqueous sodium sulfite and after column chromatography yielded 4-amino-3-iodo-5-nitrotoluene (14.2 g). δ (360 MHz, DMSO-d6) 2.19 (3H, s, CH3), 6.88 (2H, bs, NH2), 7.88 (1H, d, 2-H) and 7.94 (1H, d, 6-H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270309 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-8fa813648eaa4bf4aac429db349dbe1b |
| 出典メモ | uspto-grants-1993_12 |