化工社化工社 化学情報印刷レポート · 研究参考用
Cumene → N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cumene | HCID 7406 | — |
| 反応物 | 4-(Propan-2-yl)benzene-1-sulfonyl chloride | HCID 2734882 | — |
| 反応物 | 4,6-Dichloro-5-(4-methoxyphenyl)pyrimidine | HCID 19735458 | — |
| 反応物 | p-Isopropylbenzenesulfonamide potassium | HCID 67849051 | — |
| 生成物 | N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide | HCID 19735327 | 57.5% |
反応手順
p-Isopropylbenzenesulfonyl chloride, boiling point 105° C./0.25 Torr, was prepared from cumene and converted into the corresponding sulfonamide, melting point 104°-105° C. Reaction of 765 mg of 4,6-dichloro-5-(p-methoxyphenyl)-pyrimidine and 925 mg of p-isopropylbenzenesulfonamide potassium yielded 720 mg of N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide, melting point 181°-182° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270313 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-2833a550aa704032979e5f70f721a3a7 |
| 出典メモ | uspto-grants-1993_12 |