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Formamidine → 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formamidine | HCID 68047 | — |
| 反応物 | Diethyl 2-(2-chlorobenzyl)malonate | HCID 12661049 | — |
| 生成物 | 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone | HCID 19735337 | — |
反応手順
Condensation of diethyl o-chlorobenzylmalonate with formamidine yielded 5-(o-chlorobenzyl)-6-hydroxy-4(3H)-pyrimidinone which, by reaction with phosphorus oxychloride, yielded 4,6-chloro-5-(o-chlorobenzyl)pyrimidine, melting point 110°-112° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270313 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-938cb0896f2a4a44bf376abc087d4d14 |
| 出典メモ | uspto-grants-1993_12 |