化工社化工社 化学情報印刷レポート · 研究参考用
2-(3,4-Dichlorophenyl)acetyl chloride → 1-(3,4-Dichlorophenylacetyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(3,4-Dichlorophenyl)acetyl chloride | HCID 2758149 | — |
| 反応物 | 1-Methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride | HCID 18915109 | — |
| 生成物 | 1-(3,4-Dichlorophenylacetyl)-4-methyl-2-(pyrrolidin-1-ylmethyl)piperazine dihydrochloride | HCID 18915024 | 127.3% |
反応手順
The procedure described in Example 17. but using 1.0 g of 1-methyl-3-(pyrrolidin-1-ylmethyl)piperazine trihydrochloride, 2.1 ml of tciethylamine and 0.8 g of 3,4-dichlorophenylacetyl chloride, to afford 1.01 g of the title compound, melting at 223°-227° C. (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270327 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-56979dbb60a24e54b0395423b0b3e6c5 |
| 出典メモ | uspto-grants-1993_12 |