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3,5-Dimethylaniline → 4-(2-[2-Trifluoromethylphenyl]acetamido)-2,6-dimethylbenzenesulfonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Dimethylaniline | HCID 7949 | — |
| 反応物 | Calcium Carbonate | HCID 10112 | — |
| 反応物 | Chlorosulfonic acid | HCID 24638 | — |
| 反応物 | 2-(Trifluoromethyl)phenylacetyl chloride | HCID 13201823 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(2-[2-Trifluoromethylphenyl]acetamido)-2,6-dimethylbenzenesulfonyl chloride | HCID 19926639 | 47% |
反応手順
4-(2-[2-Trifluoromethylphenyl]acetyl)-3,5-dimethylaniline (obtained as a solid, m.p. 168° C., by reacting 2-(2-trifluoromethylphenyl)acetyl chloride with 3,5-dimethylaniline in THF solution in the presence of calcium carbonate) was reacted with an excess of chlorosulfonic acid at 60° C., using an analogous procedure to that described in Organic Synthesis, Coll. Vol. I, at page 85, to give 4-(2-[2-trifluoromethylphenyl]acetamido)-2,6-dimethylbenzenesulfonyl chloride, as a solid in about 47% yield, which was used without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270342 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-984f32a150834af2bae029f254ed9e16 |
| 出典メモ | uspto-grants-1993_12 |