Ammonia → 2-(2,3-Dichlorophenoxy)acetamidine hydrochloride

HRID 326834ノート

反応式

HRID 326834 の反応式
Cl.[Cl:2][C:3]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C:7](=[NH:11])OCC.[NH3:17]>C(O)C>[ClH:2].[Cl:2][C:3]1[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][C:4]=1[O:5][CH2:6][C:7]([NH2:11])=[NH:17]

参加物

4

反応物 2

HCID 222AmmoniaHCID 19736212Ethyl 2-(2,3-dichlorophenoxy)acetimidate hydrochloride

生成物 1

HCID 197362082-(2,3-Dichlorophenoxy)acetamidine hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

11.8 g (0.041 mole) of ethyl 2-(2,3-dichlorophenoxy)acetimidate hydrochloride are added rapidly to a solution, cooled to 10° C., of 3.5 g (0.21 mole) of ammonia in 100 ml of absolute ethanol. The reaction mixture is left for 3 days at room temperature. After removal of a few suspended particles by filtration, the reaction mixture is concentrated to dryness under reduced pressure. The solid residue obtained is purified by washing with ether and recrystallization from isopropanol. Yld: 8.0 g (75%), m.p. 204.5°-206.5° C.

後処理

  1. customAfter removal of
  2. filtrationby filtration
  3. concentrationthe reaction mixture is concentrated to dryness under reduced pressure
  4. customThe solid residue obtained
  5. customis purified
  6. washby washing with ether and recrystallization from isopropanol

出典と根拠

ORDレコード
ord-36c2428da5f544928735c639c6d2e630
出典データセット
uspto-grants-1993_12
特許番号
US05270465

反応ノート

読み込み中…