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3-Aminopyrazine-2-carbonitrile → 4-Amino-2-[(4-methylphenoxy)methyl]pteridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminopyrazine-2-carbonitrile | HCID 817699 | — |
| 反応物 | 2-(4-Methylphenoxy)acetamidine | HCID 13430822 | — |
| 反応物 | Acetone ethanol | HCID 21889777 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Amino-2-[(4-methylphenoxy)methyl]pteridine | HCID 10587889 | — |
反応手順
Obtained using the procedure described in section c of Example 2, starting with 6.9 g (0.057 mole) of 3-amino-2-pyrazinecarbonitrile and 14.1 g (0.086 mole) of 2-(4-methylphenoxy)acetamidine [prepared according to C. Djerassi and C. R. Scholz, U.S. Pat. No. 2,517,468; C.A. 1951, 45, 661f] in 350 ml of absolute ethanol. Refluxing time: 2 hours. Yld: 2.6 g (17%), m.p. 225°-227° C. (acetone/ethanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270465 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-1e08b584bc8d4f4cbe3a062944c9c19e |
| 出典メモ | uspto-grants-1993_12 |