Morpholine → 5-Ethylsulfamoyl-2-morpholin-4-yl-benzoic acid

反応式

CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:34])(=[O:33])[NH:30][CH2:31][CH3:32])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1>>[CH2:31]([NH:30][S:29]([C:26]1[CH:27]=[CH:28][C:20]([N:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)=[C:21]([CH:25]=1)[C:22]([OH:24])=[O:23])(=[O:34])=[O:33])[CH3:32]

参加物

反応物 3

HCID 8083Morpholine

HCID 167683232-Chloro-5-(ethylsulfamoyl)benzoic acid

HCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

生成物 1

HCID 597935325-Ethylsulfamoyl-2-morpholin-4-yl-benzoic acid収率 42%

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-ethylsulfamoyl-benzoic acid and morpholine and obtained in 42% yield. MS (m/e): 313.2 (MH−, 100%).