化工社化工社 化学情報印刷レポート · 研究参考用
3,4-dihydro-2H-pyran → 2-[(3-Bromophenyl)methoxy]oxane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | Triphenylphosphonium bromide | HCID 80811 | — |
| 反応物 | 3-Bromobenzyl alcohol | HCID 85141 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-[(3-Bromophenyl)methoxy]oxane | HCID 15282064 | — |
反応手順
The alcohol of Step 1 (41.23 mmol), dihydropyran (12.5 mL, 137 mmol) and triphenylphosphine hydrobromide (725 mg, 2.11 mmol) were mixed together in 200 mL of CH2Cl2 and stirred for 2 days. The solvent was then evaporated and the title product was purified by flash chromatography on silica using EtOAc:toluene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05270324 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-c2ae1008ecfd42148dc93d7121468a10 |
| 出典メモ | uspto-grants-1993_12 |