tert-Butyl piperazine-1-carboxylate → 4-(2-Fluoro-4-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

反応式

[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Br[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=1[F:22]>>[C:4]([O:3][C:1]([N:8]1[CH2:9][CH2:10][N:11]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=2[F:22])[CH2:12][CH2:13]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

参加物

反応物 2

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 5732804-Bromo-3-fluorotoluene

生成物 1

HCID 597935814-(2-Fluoro-4-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester収率 40%

実験手順

Title compound was prepared according to the procedure described in example G from N-Boc-piperazine and 4-bromo-3-fluorotoluene (40% yield, yellow oil, MS (m/e): 295.2 (M+H+, 100%).

出典と根拠

ORDレコード: ord-a1062e2ce66f4e638a2eee79416bf783
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07427612B2

反応ノート

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