Hydrochloric Acid → Propanamide, N-(2,3-dihydro-1H-inden-2-yl)-

HRID 327025

反応式

HRID 327025 の反応式
ClCCl.Cl.[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1.[C:15](Cl)(=[O:18])[CH2:16][CH3:17].Cl>C(N(CC)CC)C>[CH2:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:14][CH:6]1[NH:5][C:15](=[O:18])[CH2:16][CH3:17]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 62324Propionyl chlorideHCID 1227642-Aminoindan hydrochloride

生成物 1

HCID 11701165Propanamide, N-(2,3-dihydro-1H-inden-2-yl)-収率 87.2%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

200 ml of dichloromethane, then 15 ml, i.e. 10.9 g (107.6 mmmol) of triethylamine were added to 5 g (29.5 mmol) of 2-aminoindan hydrochloride. The mixture was stirred, then 2.6 ml (29.5 mmol) of propionyl chloride were added and stirring was continued at room temperature for 12 h. Dilute hydrochloric acid was added, the precipitate was filtered, washed, dried and purified by chromatography on a silica gel column, eluted with an 80:20 mixture of dichloromethane/ethyl acetate. 4.87 g of beige solid were isolated.

後処理

  1. stirringstirring
  2. filtrationthe precipitate was filtered
  3. washwashed
  4. customdried
  5. custompurified by chromatography on a silica gel column
  6. washeluted with an 80:20 mixture of dichloromethane/ethyl acetate

出典と根拠

ORDレコード
ord-d075939707894104a700c725e0acd730
出典データセット
uspto-grants-1993_12
特許番号
US05272157

関連ノート

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