4-Chlorobenzylamine → N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamide

HRID 327092ノート

反応式

HRID 327092 の反応式
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([Cl:13])=[CH:15][CH:16]=1)#[N:2]

参加物

4

反応物 2

HCID 660364-ChlorobenzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

生成物 1

HCID 19734551N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamide収率 16.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 4-chlorobenzylamine (0.48 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 5 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.13 g, 0.5 mmol, yield: 16%) as colorless crystals.

後処理

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

出典と根拠

ORDレコード
ord-1bbfd302da1e4f7b950993b809a51943
出典データセット
uspto-grants-1993_12
特許番号
US05272164

反応ノート

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