Acetic Acid → Methyl 3-quinolinecarboximidate

HRID 327128ノート

反応式

HRID 327128 の反応式
[C:1]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2)#[N:2].C[O-].[Na+].[C:16](O)(=[O:18])C>CO>[N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:12]=[C:3]([C:1](=[NH:2])[O:18][CH3:16])[CH:4]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 931773-QuinolinecarbonitrileHCID 10942334Sodium Methoxide

生成物 1

HCID 19734518Methyl 3-quinolinecarboximidate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-cyanoquinoline (1.58 g, 10.2 mmol) was dissolved in methanol (20 ml), and sodium methoxide (0.06 g, 1.1 mmol) was added. The reaction was conducted at room temperature for 22 hours. After the reaction was completed, acetic acid (0.07 g, 1.1 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (60 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 3-quinolinecarboximidate.

後処理

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether (60 ml) was added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-805c66f067644aaa964d24fc0ffbae3e
出典データセット
uspto-grants-1993_12
特許番号
US05272164

反応ノート

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