1-(2-Fluorophenyl)piperazine → (2-Fluoro-5-nitro-phenyl)[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

反応式

[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[F:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([N:24]1[CH2:23][CH2:22][N:21]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[F:14])[CH2:26][CH2:25]1)=[O:5]

参加物

反応物 2

HCID 705291-(2-Fluorophenyl)piperazine

HCID 109765702-Fluoro-5-nitrobenzoyl chloride

生成物 1

HCID 59793717(2-Fluoro-5-nitro-phenyl)[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

実験手順

The title compound was prepared according to the procedure described for example 46 from 2-Fluoro-5-nitro-benzoyl chloride and 1-(2-fluorophenyl)-piperazine (52%, orange solid, MS (m/e): 348.1 (M+H, 100%)

出典と根拠

ORDレコード: ord-72e1b6a028d044d0a14fe54c3ba4d0f0
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07427612B2

反応ノート

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