反応式
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)=[CH:7][CH:6]=1)(=O)C>C(O)C>[N:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:21]=[CH:22][C:13]=1[CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([NH2:4])=[CH:6][CH:7]=1参加物
3
実験手順
A suspension of N-acetyl-4-(quinolin-2-yl-methoxy)aniline (Step A, 108.9 g) in 1 L of 95% ethanol containing 10M KOH (120 mL) was heated at reflux under nitrogen in a heating mantle. When the hydrolysis was complete (approx. 36 h), the reaction mixture was cooled and ethanol was partially removed under vacuum. The mixture was then diluted with water (200 mL) and the fine off-white crystals were collected and thoroughly rinsed with water. The material, after air-drying, yielded the title compound which was used as such in the next step.
後処理
- temperaturewas heated
- temperatureat reflux under nitrogen in a heating mantle
- custom(approx. 36 h)
- temperaturethe reaction mixture was cooled
- customethanol was partially removed under vacuum
- additionThe mixture was then diluted with water (200 mL)
- customthe fine off-white crystals were collected
- washthoroughly rinsed with water
- customThe material, after air-drying
出典と根拠
- ORDレコード
- ord-ef86d1020e664a9d8a2bf81d9f148297
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05272145
関連ノート
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