Iodine → 2-Propyl-3-t-butyl-4-hydroxy-5-isopropylphenol

HRID 327324

反応式

HRID 327324 の反応式
[CH2:1]([C:4]1[C:5](=[O:18])[CH:6]=[C:7]([CH:15]([CH3:17])[CH3:16])[C:8](=[O:14])[C:9]=1[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:2][CH3:3].C[SiH](C)O[SiH](C)C.II>C(Cl)Cl>[CH2:1]([C:4]1[C:9]([C:10]([CH3:12])([CH3:11])[CH3:13])=[C:8]([OH:14])[C:7]([CH:15]([CH3:17])[CH3:16])=[CH:6][C:5]=1[OH:18])[CH2:2][CH3:3]

参加物

5

反応物 3

HCID 807IodineHCID 186591,1,3,3-Tetramethyl-disiloxaneHCID 570664232-Propyl-3-t-butyl-5-isopropylbenzoquinone

生成物 1

HCID 540178862-Propyl-3-t-butyl-4-hydroxy-5-isopropylphenol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Dissolve 2-propyl-3-t-butyl-5-isopropylbenzoquinone (10mmol), 1,1,3,3-tetramethyldisiloxane (1.79mL, 10mmol) and iodine (0.05g) in methylene chloride (30mL). Stir at reflux for 30 minutes and extract with 1N sodium hydroxide (30mL). Acidify the aqueous phase with concentrated hydrochloric acid and extract into ethyl acetate (4×10mL), dry (NazSO4) and evaporate the solvent in vacuo to give 2-propyl-3-t-butyl-4-hydroxy-5-isopropylphenol.

後処理

  1. temperatureat reflux for 30 minutes
  2. extractionextract with 1N sodium hydroxide (30mL)
  3. extractionextract into ethyl acetate (4×10mL)
  4. customdry (NazSO4)
  5. customevaporate the solvent in vacuo

出典と根拠

ORDレコード
ord-b46a9b0399e14315810fcbac9dd0be5b
出典データセット
uspto-grants-1993_12
特許番号
US05272252

関連ノート

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