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Dicyclohexylcarbodiimide → Maleimidoacetic acid N-hydroxysuccinimide ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 反応物 | 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid | HCID 319935 | — |
| 溶媒 | Diglyme | HCID 8150 | — |
| 生成物 | Maleimidoacetic acid N-hydroxysuccinimide ester | HCID 3299229 | 99.1% |
反応手順
Maleimidoacetic acid (155 mg, 1.0 mmol) in 5 ml of diglyme was treated at 0° C. with N-hydroxysuccinimide (127 mg, 1.1 mmol) and dicyclohexylcarbodiimide (227 mg, 1.1 mmol). After 1 hour at 0° C. and 3 hours at room temperature, the reaction mixture was filtered and evaporated to dryness to yield 0.25 g of crude maleimidoacetic acid N-succinimidyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05273743 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-af1dc5f34405494aaf454788d0f1a090 |
| 出典メモ | uspto-grants-1993_12 |