Ammonia → Ethyl 1-methyl-beta-oxocyclopropanepropanoate
反応式
[CH3:1][C:2]1([C:5]([CH:7](C(=O)C)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6])[CH2:4][CH2:3]1.N>C(O)C>[CH3:1][C:2]1([C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6])[CH2:3][CH2:4]1参加物
4
実験手順
A solution comprising 55 grams of ethyl 2-(1-methylcyclopropanecarbonyl)-3-oxobutanoate and 160 ml of ethanol was stirred at room temperature and 60 ml of a 30% aqueous ammonia solution was added dropwise to this solution over a period of 10 minutes. Subsequently, the mixture was stirred for 1 hour and extracted with 300 ml of ethyl acetate and dilute aqueous hydrochloric acid. After neutralization and washing with water, the organic layer was dried over anhydrous sodium sulfate. The solvent was then removed and 43 grams of ethyl (1-methylcyclopropanecarbonyl)acetate was obtained as an oily material.
後処理
- stirringSubsequently, the mixture was stirred for 1 hour
- extractionextracted with 300 ml of ethyl acetate and dilute aqueous hydrochloric acid
- washAfter neutralization and washing with water
- dry with materialthe organic layer was dried over anhydrous sodium sulfate
- customThe solvent was then removed
出典と根拠
- ORDレコード
- ord-7db4c978c0524eaf9adf6835c331852d
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05273868
反応ノート
読み込み中…