Piperidine → HCID 19108415、化合物

HRID 327391

反応式

HRID 327391 の反応式
[CH2:1]=[C:2]1[C:7](=[O:8])[CH:6]2[CH2:9][CH2:10][N:3]1[CH2:4][CH2:5]2.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>CCCCCC>[N:11]1([CH2:1][CH:2]2[C:7](=[O:8])[CH:6]3[CH2:9][CH2:10][N:3]2[CH2:4][CH2:5]3)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 8082PiperidineHCID 3229732-Methylene-3-quinuclidone

生成物 1

HCID 19108415HCID 19108415、化合物収率 99.2%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

A reaction flask containing 2-methylenequinuclidin-3-one (6.86 g, 50 mmoles) and a magnetic stir bar was charged with piperidine (12 ml, 120 mmoles). The mixture was stirred at room temperature for 18 hours, and the mixture was added to hexane (300 ml). The solution was filtered through Celite® and the filtrate was concentrated in vacuo (maximum temperature 60° C.) to provide 11.03 g (99%) of the product as a pale yellow solid, mp 34°-37° C.

後処理

  1. filtrationThe solution was filtered through Celite®
  2. concentrationthe filtrate was concentrated in vacuo (maximum temperature 60° C.)

出典と根拠

ORDレコード
ord-bd0ee1cd5ce24034b39a8c8013ce4fb0
出典データセット
uspto-grants-1993_12
特許番号
US05273972

関連ノート

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