Benzoyl Peroxide → 2-Chloromethyl-1,6-naphthyridine
反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[N:3]=1.[Cl:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Cl:12][CH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[N:3]=1参加物
5
実験手順
To a solution of 2-methyl-1,6-naphthyridine (E. M. Hawes, J. Heteroc. Chem. 11(2), 151 (1974)) (3.8 g) in CCl4 (230 mL) were added N-chlorosuccinimide (4.2 g) and benzoylperoxide (320 mg). The mixture was brought to reflux with two 150-watt spotlights and irradiated for 4 hr. The mixture was then cooled to room temperature, evaporated to dryness, and chromatographed on flash silica gel using ethyl acetate:toluene (1:1) as eluant to give the title compound, 80% pure and used as is for the next step.
後処理
- temperatureto reflux with two 150-watt spotlights
- customirradiated for 4 hr
- customevaporated to dryness
- customchromatographed on flash silica gel
出典と根拠
- ORDレコード
- ord-eb51386eccc447b5866a91f349b3ac5b
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05273980
反応ノート
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