3-Hydroxypiperidine → Rac-2-(3-hydroxy-piperidin-1-yl)-5-methanesulfonyl-benzoic acid

HRID 32743

反応式

HRID 32743 の反応式
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29]([CH3:32])(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[OH:33][CH:34]1[CH2:39][CH2:38][CH2:37][NH:36][CH2:35]1>>[OH:33][CH:34]1[CH2:39][CH2:38][CH2:37][N:36]([C:20]2[CH:28]=[CH:27][C:26]([S:29]([CH3:32])(=[O:31])=[O:30])=[CH:25][C:21]=2[C:22]([OH:24])=[O:23])[CH2:35]1

参加物

4

反応物 3

HCID 232933-HydroxypiperidineHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

生成物 1

HCID 59793490Rac-2-(3-hydroxy-piperidin-1-yl)-5-methanesulfonyl-benzoic acid収率 9%

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example Y) from 2-Chloro-5-methanesulfonyl-benzoic acid and rac-3-hydroxy-piperidine and obtained in 9% yield. MS (m/e): 298.1 (M−H 100%).

後処理

  1. customobtained in 9% yield

出典と根拠

ORDレコード
ord-d594005021914311880238702fbd4221
出典データセット
uspto-grants-2008_09
特許番号
US07427612B2

関連ノート

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