Hydrochloric Acid → 2,3,6,7-tetrahydro-3-oxo-1H,5H-benzo(ij) quinolizin-2-amine hydrochloride
反応式
[O:1]=[C:2]1[CH:11]([NH:12]C=O)[CH2:10][C:9]2=[CH:15][CH:16]=[CH:17][C:7]3=[C:8]2[N:3]1[CH2:4][CH2:5][CH2:6]3.C(O)C.CCOCC.[ClH:26]>>[ClH:26].[O:1]=[C:2]1[CH:11]([NH2:12])[CH2:10][C:9]2=[CH:15][CH:16]=[CH:17][C:7]3=[C:8]2[N:3]1[CH2:4][CH2:5][CH2:6]3参加物
5
実験手順
A solution of N-(2,3,6,7-tetrahydro-3-oxo-1H,5H-benzo(ij)quinolizin-2-yl)-formamide (0.8 g, 3.4 mmol) in ethanolic hydrogen chloride (10 mL of 4.2 M) was heated at 50° C. for 2 hours. The ethanol was cooled, an equal volume of ether was added, and the precipitate was filtered off and washed with ether to give 0.78 g of 2,3,6,7-tetrahydro-3-oxo-1H,5H-benzo(ij)quinolizin-2-amine hydrochloride, mp 216°-221° C. The product was recrystallized for analysis; mp 219°-222° C. Anal. Calcd. for C12H14N2O.HCl: C, 60.37; H, 6.33; Cl, 14.85; N, 11.74. Found: C, 59.89; H, 6.42; Cl, 15.41; N, 11.68.
後処理
- filtrationthe precipitate was filtered off
- washwashed with ether
出典と根拠
- ORDレコード
- ord-c95de2c958924b289cb886245c9b9b10
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05273975
反応ノート
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