関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | 2,3-Diaminotoluene | HCID 17593 | — |
| 生成物 | 4-Methylbenzimidazole | HCID 1519341 | 90% |
反応手順
A mixture of 3-methyl-1,2-benzenediamine (11.9 g) and formic acid (150 mL) was heated at 70° C. for 15 minutes. The solvent was removed under reduced pressure and the residual oil was stirred with water (100 mL) and sodium hydroxide solution (65 mL of 4.0 N) was added until the solution was just basic. The precipitate was filtered off, washed with water, and air dried to give 11.6 g (90%) of 4-methyl-1H-benzimidazole, mp 141°-145° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05273975 |
|---|
| 出典データセット | uspto-grants-1993_12 |
|---|
| ORD ID | ord-3592da26c31349c4ad925e57eefe2413 |
|---|
| 出典メモ | uspto-grants-1993_12 |
|---|
