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3-Hydroxypiperidine → Rac-2-(3-hydroxy-piperidin-1-yl)-5-methylsulfamoyl-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxypiperidine | HCID 23293 | — |
| 反応物 | Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]- | HCID 111724 | — |
| 反応物 | 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid | HCID 59793489 | — |
| 生成物 | Rac-2-(3-hydroxy-piperidin-1-yl)-5-methylsulfamoyl-benzoic acid | HCID 59793580 | 15% |
反応手順
The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-methylsulfamoyl-benzoic acid and rac-3-hydroxy-piperidine and obtained in 15% yield. MS (m/e): 312.9 (MH− 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07427612B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-36919d26d00f4ef1a0e891b347c58139 |
| 出典メモ | uspto-grants-2008_09 |