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Hydrochloric Acid → 3,4,5-Trimethoxyphenylacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3,4,5-Trimethoxyphenylacetonitrile | HCID 25887 | — |
| 反応物 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | 3,4,5-Trimethoxyphenylacetic acid | HCID 70372 | — |
反応手順
3,4,5-trimethoxyphenyl acetonitrile 5.5 g was dissolved into 50 ml of methanol/water (9:1). To this 1 .5 g of sodium hydroxide was added and they were then stirred and refluxed for 5.5 hours. The temperature of the reactive liquid was lowered down to room temperature and neutralized with 2N hydrochloric acid, and the methanol was distilled off under reduced pressure. Extraction was performed thrice by means of 100 ml of chloroform. After distilling off the solvent under reduced pressure, 5.8 g of captioned compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05273985 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-e7187962b89b4a35b63770f24bc46a23 |
| 出典メモ | uspto-grants-1993_12 |