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4-Methylmorpholine → N-[4-(1-t-butoxyformamido)butyryl]-beta-alanine benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | 4-(((Tert-butoxy)carbonyl)amino)butanoic acid | HCID 294894 | — |
| 反応物 | Chloro-dimethoxy-triazine | HCID 12493616 | — |
| 反応物 | 4-Methylbenzene-1-sulfonic acid--benzyl beta-alaninate (1/1) | HCID 13502100 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-[4-(1-t-butoxyformamido)butyryl]-beta-alanine benzyl ester | HCID 19926286 | — |
反応手順
4-(t-Butoxycarbonylamino)butyric acid in THF was activated with chlorodimethoxytriazine and N-methylmorpholine and reacted with β-alanine benzyl ester p-toluenesulphonate in the presence of N-methylmorpholine to give N-[4-(1-t-butoxyformamido)butyryl]-β-alanine benzyl ester, m.p. 54°-55° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05273982 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-6b91b2e342c84db5ba17df2855251161 |
| 出典メモ | uspto-grants-1993_12 |