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Homophthalic anhydride → 2-({3-[(E)-2-(4-Isopropyl-thiazol-2-yl)-vinyl]-phenylcarbamoyl}-methyl)-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Homophthalic anhydride | HCID 12801 | — |
| 反応物 | 4-Isopropyl-2-(trans-3-aminostyryl) thiazole | HCID 14051165 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-({3-[(E)-2-(4-Isopropyl-thiazol-2-yl)-vinyl]-phenylcarbamoyl}-methyl)-benzoic acid | HCID 9844251 | 85.2% |
反応手順
A mixture of 1.2 g of (E)-3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]benzeneamine, 0.8 g of homophthalic anhydride and 25 ml of toluene was heated to reflux for 0.5 hr. Upon cooling to room temperature, the solid reaction product was filtered and washed with ethyl ether to yield 1.7 g of (E)-2-[2-[3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid. Recrystallization from ethyl alcohol yielded off-white solid material; m.p. 203°-204° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05273986 |
| 出典データセット | uspto-grants-1993_12 |
| ORD ID | ord-8d03b41a1581486ab8b8edb1afc61a2d |
| 出典メモ | uspto-grants-1993_12 |